(alphabetically organized)

** WARNING: CONTAINS MAJOR SPOILERS. PROCEED WITH CAUTION**

A
abusive relationship (emotional parental)
ageism (jokes)
amputation (single joke)
animal abuse (sarcasm/Tiger King joke)

B
blood
bullying (reference to off-screen name calling)

C
cannibalism (sarcastic joke)
child abuse (verbal and emotional abuse, abandonment by parents)
classism (byproduct of most characters being filthy rich)

D
death/dying (reference off-screen)
death penalty (single reference in joke)
decapitation (of a crawfish)
drinking (heavy for 2-3 chapters)
drug use (prescription, mentioned a few times for headaches)

E
ED (binge eating by supporting character, not as ED)

F
forced captivity (dubious consent)

G
graphic sex (lots and lots :/)
guns (and flamethrowers)

H
Hospitalization (a few chapters, not serious)

N
needles (brief description of IV in hospital)

P
pedophilia (single joke in Ch. 17)
pregnancy (several references and jokes)
prostitution (jokes in ch 5 and ch 46)
PTSD (not explicitly described, but trauma from emotionally abusive parents)

S
serious injury
sexism
suicidal thoughts (off-hand threats by side character)
swearing (a shit ton)

V
vomit (one depiction)

W
weapons (brief references to tanks, guns, and flamethrowers)